Floating microspheres of acyclovir pdf

Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres. The objective was to develop floating microspheres of vch to localise the drug at upper part of git, for improved absorption. Pharmacokinetic study in rats showed nearly two times higher auc value of acyclovir for the microspheres with piperine 15614. In vitro evaluation of acyclovirchitosan floating systems mdpi. Microspheres formulated from biodegradable particles such as polyd, llactide and polyd, llactidecoglycolide with encapsulated antiviral drug acyclovir have been proposed for intraocular. Pdf preparation and in vitro evaluation of floating microspheres. Floating microspheres have been gaining attention due. The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 251 387 m, 74. Formulation and evaluation of sustained release gastro. Floating microspheres are, in a strict sense, spherical empty particles without a core. Choudhary, department of pharmaceutics, alameen college of pharmacy, near lalbagh main gate, hosur road, bangalore 560027, india department of pharmaceutics, alameen college of pharmacy, near. Pdf multiunit floating drug delivery system of acyclovir. Formulation and invitro characterization of acyclovir floating. Formulation and in vitro evaluation of floating microspheres of.

The floating microspheres of acv are potential drug delivery system for the enhancement of oral bioavailability of acv. Hollow microspheres of acyclovir hollow microspheres of acyclovir were prepared by the methoddescribedaboveandusing1gofeudragits100anddifferent amounts 100, 200, 400, 600 and 800 mg of acyclovir. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the release of. The prepared floating microspheres were evaluated for flow properties by. Acyclovir loaded floating microspheres were prepared by emulsion solvent diffusion method with combination of polymers. The 3 2 full factorial design was applied to optimize the formulation. The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Pdf preparation and in vitro evaluation of floating. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. Preparation and in vitro evaluation of floating microspheres of gabapentin and acyclovir. Microspheres are able to incorporate a wide range of different drugs, they are biocompatible and can be prepared from biodegradable particles. Floating properties and release characteristics of hollow. The resulting slurry was introduced into a 250 ml beaker containing 200 ml 0.

Development and evaluation of floating microspheres of. Keywords acyclovir, eudragit s100, floating microspheres, hollow. The collected microspheres were dried in desiccators over night. Pornsuwannapha developed hollow microspheres of acv that were capable of floating on gastric. Sustained release floating microspheres of acyclovir.

Microspheres were having sufficient entrapment efficiency and floating ability and were directly proportional to the polymer concentration. The microspheres were prepared by emulsion solvent evaporation method using polymers hydroxyl propyl methyl cellulose, ethyl cellulose, eudragit s100 and eudragit rl. In thismethod, acyclovirpowderwasaddedtodichloromethanebefore adding to the polymer solution of ethanol and isopropanol. Valacyclovir hydrochloride vch is lvalyl ester prodrug of acyclovir. Multiunit floating drug delivery system of acyclovir. Merck manual online drug library and uchida t, yoshida k. Acyclovir loaded floating microspheres were prepared by double emulsion solvent evaporation method. The present study involves preparation and evaluation of floating microspheres of acyclovir as model drug for prolongation of gastric residence time. Preparation of floating microspheres floating microspheres were prepared by emulsion solvent diffusion method 7. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the.

Rjpt development and characterization of cellulose and. The highest percent drug entrapment was obtained at the ratio of 600 mg acyclovir. Pdf sustained release floating microspheres of acyclovir. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy. Floating microspheres are multiple unit gastroretentive drug delivery systems. The purpose of the present study was preparation and in vitro evaluation of the floating microspheres of two drugs gabapentin and acyclovir as gastroretentive drug delivery systems. The hollow microspheres of acyclovir were prepared by spraydrying method using ethyl cellulose as a drugcontrolled release polymer. Floating properties and release characteristics of.