Floating microspheres of acyclovir pdf

Floating microspheres have been gaining attention due. Formulation and invitro characterization of acyclovir floating. Rjpt development and characterization of cellulose and. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy. The prepared floating microspheres were evaluated for flow properties by. Floating microspheres are, in a strict sense, spherical empty particles without a core.

The hollow microspheres of acyclovir were prepared by spraydrying method using ethyl cellulose as a drugcontrolled release polymer. Pharmacokinetic study in rats showed nearly two times higher auc value of acyclovir for the microspheres with piperine 15614. Microspheres were having sufficient entrapment efficiency and floating ability and were directly proportional to the polymer concentration. Valacyclovir hydrochloride vch is lvalyl ester prodrug of acyclovir. In vitro evaluation of acyclovirchitosan floating systems mdpi. Microspheres formulated from biodegradable particles such as polyd, llactide and polyd, llactidecoglycolide with encapsulated antiviral drug acyclovir have been proposed for intraocular.

Preparation and in vitro evaluation of floating microspheres of gabapentin and acyclovir. Formulation and evaluation of sustained release gastro. Pdf sustained release floating microspheres of acyclovir. Floating microspheres are multiple unit gastroretentive drug delivery systems. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the release of. The resulting slurry was introduced into a 250 ml beaker containing 200 ml 0. The floating microspheres of acv are potential drug delivery system for the enhancement of oral bioavailability of acv. Microspheres, solvent evaporation diffusion, controlled.

Acyclovir loaded floating microspheres were prepared by emulsion solvent diffusion method with combination of polymers. Preparation of floating microspheres floating microspheres were prepared by emulsion solvent diffusion method 7. The collected microspheres were dried in desiccators over night. The objective was to develop floating microspheres of vch to localise the drug at upper part of git, for improved absorption. Introduction acyclovir 92hydroxyethoxymethyl guanine. In thismethod, acyclovirpowderwasaddedtodichloromethanebefore adding to the polymer solution of ethanol and isopropanol. Pornsuwannapha developed hollow microspheres of acv that were capable of floating on gastric. Floating properties and release characteristics of. Merck manual online drug library and uchida t, yoshida k. Multiunit floating drug delivery system of acyclovir. Designing development and evaluation of floating gastro. Pdf multiunit floating drug delivery system of acyclovir. The present study involves preparation and evaluation of floating microspheres of acyclovir as model drug for prolongation of gastric residence time. Keywords acyclovir, eudragit s100, floating microspheres, hollow.

Sustained release floating microspheres of acyclovir. The drug is released slowly at the desired rate, and the system is found to be floating on gastric content and increases gastric. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres. The microspheres were prepared by emulsion solvent evaporation method using polymers hydroxyl propyl methyl cellulose, ethyl cellulose, eudragit s100 and eudragit rl. Development and evaluation of floating microspheres of. The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. The highest percent drug entrapment was obtained at the ratio of 600 mg acyclovir. Pdf preparation and in vitro evaluation of floating microspheres. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the. Formulation and in vitro evaluation of floating microspheres of. Choudhary, department of pharmaceutics, alameen college of pharmacy, near lalbagh main gate, hosur road, bangalore 560027, india department of pharmaceutics, alameen college of pharmacy, near.